Once there is an error on a skuid page then I am unable to select any data(lookup values) or render

Are you putting your Apex call in a jquery deferred promise block so that you can be assured of success, and appropriately handle errors in the Asynch Apex process?  
More information is here: https://community.skuid.com/t/block-ui-and-show-message-until-sforce-connection-remote…  or in other posts on the community.