Conditionally applying CSS would be less intimidating if Skuid did the work. If there were an action for "apply CSS" and an option in the conditional rendering section for "apply CSS" I think it would make things like "make font red it this field says x" much easier and more frequently used.
One additional detail. In the CSS section there would be an option for "apply on page load". If selected, CSS would behave as it does now. If deselected, the CSS would not be applied until an action or render condition calls on it.